{"route":"/api/pharos/run","generated_by":"PHAROS deterministic pharmacovigilance runner","engine_version":"pharos-pharmacovigilance-runner-v0.2.0","corpus_seal":"sha256:82e6d981723a23224a58b0964b5b64e42b3e53f5d931aa221ce8a71b828fa940","benchmark_packet":{"source":"COSMIC PHAROS benchmark package plus SIGNAL result packet cosmic5_20260420_122022","caveat":"PHAROS prioritizes adverse-event signals for review. It does not declare clinical causality, regulatory action, or medical advice.","signal":{"drug_event_pairs":36,"faers_records":"17.76M","quarters":"44 quarters","baseline_methods":"PRR, ROR, BCPNN, MGPS","detection_rate":"63.9%","detection_count":"23/36","detection_ci":"47.2%-77.8%","median_lead_time":"24.3 months","lead_time_ci":"17.8-33.2 months","prr_detection":"22/36","ror_detection":"23/36","bcpnn_detection":"23/36","mgps_detection":"19/36","baseline_context":"Matches ROR and BCPNN by detection count, beats PRR by one case and MGPS by four cases, and adds calibrated abstention.","output_boundary":"priority signal, monitor, or refused packet","receipt_posture":"SHA-linked source chain from document to finding"},"headline":"PHAROS applies COSMIC to 36 FDA black-box drug-event pairs across 17.76M FAERS records, matching established signal methods while adding calibrated abstention."},"sample_packets":[{"id":"priority-signal","label":"Prioritize signal"},{"id":"monitor-noisy","label":"Monitor noisy packet"},{"id":"refuse-causality","label":"Refuse causality overclaim"},{"id":"baseline-table","label":"Baseline table"}],"pipeline":["METEOR","NOVA","ECLIPSE","PULSAR","AURORA"],"source_alignment":{"cosmic_package":"benchmarks.pharos","baseline_package":"baselines.pharos","deployed_runtime":"TypeScript port of PRR/ROR/BCPNN/MGPS math plus PHAROS COSMIC scoring rules"}}